I like Erik's suggested template, it's quite simple and won't mean you have to rely on pots and if you make a mistake you won't pay heavily for it. If you aren't a very experienced player I'd go for that one although you could adjust it slightly to get more out of the points:
fencing 110anatomy 100healing 90 - healing of 90.1 is 100% succeed rate so at 90 it's reliable and you only lose about 2 heal points.
hiding/stealth 80 - you don't go anywhere too quick. I'd keep them at this though due to it being a crammed template already, you need all the points you can get!
ninjitsu 110 - Higher you can get this the better tbh, Death strike is a fantastic move!
focus 60 - you get 1 mana regen for every 20 focus, 1 stam regen for every 10. there are no in between points so only ever put it up in 20s unless you have such an uncrammed template you can afford to jump by 10 for the extra stam regen.
poisoning 70 - poisoning is instantly cured with a cure pot and everyone uses them, I wouoldn't worry too much about what level of poisoning you're doing. only lethal poison is really very worthwhile.
That all adds upto 700, any extra points i'd put in more fencing if you can afford the scroll or more ninjitsu if you can afford it. Otherwise either more poisoning or maybe 20 extra focus to help with mana and stamina. Remember, if you have ML then you have 20 tactics already along with every other skill, so no point in putting 20 random points in a skill.
Stats wise I'd probably go:
str 80-90
dex 90
int 55-45
That's with 225 stats, if you have more and stat scrolls are super cheap, I'd put more in Str and Dex. With 250 stats I'd probably go:
str 100
dex 100
int 50
basically, make sure you have at least 50 mana and never over 100 str (pointless really). Dex is something that isn't so vital but also very handy to have as high as you can get it. Don't sacrifice str or int for it though! That is a big mistake many people make in the hope of swinging faster.